Norditropin Simplex contains a biosynthetic human growth hormone called somatropin which is identical to the growth hormone produced naturally in the body. It is a form of human growth hormone. Children need growth hormone to help them grow but adults also need it for their general health.
Norditropin injection is used to treat growth failure in children and adults who lack natural growth hormone, chronic kidney failure, Noonan syndrome, Turner syndrome, short stature at birth with no catch-up growth and other causes. It is also used to prevent severe weight loss in people with AIDS or to treat short bowel syndrome.
Human growth hormone (HGH) is responsible for bone growth as well as protein and carbohydrate metabolism in the body. In body, It is separated from the anterior pituitary (adenohypophysis). This freed Growth Hormone itself has no direct effect and stimulates the liver to produce and release insulin-like growth factor IGF-1. Its effect is expressed in increased metabolism and particularly protein synthesis.
The Norditropin dosage and administration schedule should be individualized based on the growth response of each patient. Serum insulin like growth factor I (IGF-I) levels may be useful during dose titration.
Norditropin Simplex is used as a growth hormone replacement in adults, if their growth hormone production has been decreased since childhood or has been lost in adulthood because of a tumour, treatment of a tumour or a disease that affects the gland which produces growth hormone.